Yes, but I didn't notice any symptoms or difference, so I stopped after about a year. However , now I find out progesterone helps to stop Endo from growing. So I'm now 49 had total abdominal hysterectomy, and in full menopause(which also sucks, but in less painful ways). I had been wearing estrogen patches for 20 years now, and I got a new obgyn and she just put me on progesterone. Idk if that helped answer your question. Hugs