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List of Treatments for Endometriosis

See what members are saying about endometriosis treatments, the side effects to expect, and the drug basics.

All treatment information is medically reviewed · July 3, 2025

Aygestin, Errin, Primolut N (Norethisterone)

Overview
Norethisterone is a prescription drug that was approved by the U.S. Food and Drug Administration (FDA) in 1973 to prevent pregnancy. Norethisterone is also prescribed to treat symptoms of endometriosis…

Celexa (Citalopram hydrobromide)

Overview
Celexa is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to treat depression. Celexa is sometimes prescribed off-label to treat symptoms of endometriosis. Celexa is also referred to…

Cymbalta (Duloxetine)

Overview
Cymbalta is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to treat major depressive disorder, generalized anxiety disorder, and chronic pain conditions including fibromyalgia…

Danocrine (Danazol)

Overview
Danocrine is a prescription drug that was approved by the U.S. Food and Drug Administration (FDA) in 1976 to treat endometriosis. Danocrine is not considered a first-line treatment for endometriosis due to its…

Depo-Provera (Medroxyprogesterone)

Overview
Depo-Provera is a prescription drug that was approved by the U.S. Food and Drug Administration (FDA) in 1992 to prevent pregnancy. Depo-Provera is also prescribed to treat symptoms of endometriosis. Depo-Provera…

Elavil (Amitriptyline hydrochloride)

Overview
Elavil is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to treat symptoms of depression. Elavil is sometimes prescribed off-label to treat symptoms of endometriosis. Elavil is also…

Elestrin (Estradiol)

Overview
Elestrin is a prescription medication approved by the U.S. Food and Drug Administration (FDA) in 1954 to treat menopause symptoms. In cases of endometriosis, Elestrin is prescribed to reduce menopause-like side…

Errin (Norethindrone)

Overview
Errin is a prescription drug that was approved by the U.S. Food and Drug Administration (FDA) in 1973 to prevent pregnancy. Errin is also prescribed to treat symptoms of endometriosis. Errin may be referred to…

Estrace (Estradiol)

Overview
Estrace is a prescription medication approved by the Food and Drug Administration (FDA) in 1984 to treat menopause symptoms. In cases of endometriosis, Estrace is prescribed to reduce menopause-like side effects…

Lexapro (Escitalopram oxalate)

Overview
Lexapro is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to treat depression in people older than 12 years as well as generalized anxiety disorder in adults. Lexapro is sometimes…

Lupron (Leuprorelin acetate for depot suspension)

Overview
Lupron Depot is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to treat pain and reduce lesions caused by endometriosis. Lupron Depot may be referred to by its drug name, leuprolide…

Mirena (Levonorgestrel)

Overview
Mirena is an intrauterine implant approved by the U.S. Food and Drug Administration (FDA) in 1990 to prevent pregnancy and treat heavy menstrual periods. Mirena is also prescribed to treat symptoms of…

Morphine

Overview
Morphine is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to treat pain that is not responsive to non-narcotics. Morphine is sold under brand names including Astramorph and Avinza…

Myfembree (Relugolix, Estradiol, and Norethindrone Acetate)

Overview
Myfembree is approved by the U.S. Food and Drug Administration (FDA) for managing moderate to severe pain associated with endometriosis in premenopausal women, according to the drug’s prescribing information…

Nexplanon (Etonogestrel)

Overview
Nexplanon is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to prevent pregnancy. Nexplanon is sometimes prescribed off-label to treat symptoms of endometriosis. Nexplanon is also…

Norco (Hydrocodone/Acetaminophen)

Overview
Norco is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to treat moderate to moderately severe pain. Norco is a combination drug containing hydrocodone and acetaminophen. Hydrocodone…

Norethindrone (Norethisterone)

Overview
Norethisterone is a prescription drug that was approved by the U.S. Food and Drug Administration (FDA) in 1973 to prevent pregnancy. Norethisterone is also prescribed to treat symptoms of endometriosis…

Orilissa (Elagolix)

Overview
Orilissa is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to treat moderate to severe pain caused by endometriosis. Orilissa may be referred to by its drug name, elagolix
Orilissa…

Paxil (Paroxetine)

Overview
Paxil is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to treat symptoms of depression, obsessive compulsive disorder, panic disorder, social phobia, generalized anxiety disorder…

Percocet (Oxycodone/Acetaminophen)

Overview
Percocet is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to treat moderate to moderately severe pain. Percocet is a combination drug composed of oxycodone and acetaminophen…

Prometrium (Progesterone)

Overview
Prometrium is a prescription drug that was approved by the U.S. Food and Drug Administration (FDA) in 1998 to prevent endometrial hyperplasia and secondary amenorrhea. Prometrium is also prescribed to treat…

Provera (Medroxyprogesterone)

Overview
Provera is a prescription drug that was approved by the U.S. Food and Drug Administration (FDA) in 1959. Provera is prescribed to prevent pregnancy and treat symptoms of endometriosis. Provera may be referred to…

Prozac (Fluoxetine)

Overview
Prozac is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to treat major depressive disorder, bulimia nervosa, panic disorder, and obsessive compulsive disorder. Prozac is sometimes…

Synarel (Nafarelin Acetate)

Overview
Synarel is approved by the U.S. Food and Drug Administration (FDA) for the treatment of endometriosis in women 18 years of age and older, according to the prescribing label. It is indicated to relieve symptoms…

Wellbutrin (Bupropion hydrochloride)

Overview
Wellbutrin is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to treat major depressive disorder. Wellbutrin is sometimes prescribed off-label to treat endometriosis. Wellbutrin is…

Zoladex (Goserelin Implant)

Overview
Zoladex is approved by the U.S. Food and Drug Administration (FDA) for the management of endometriosis in women aged 18 years and older, according to prescribing information. It is administered for a recommended…

Zoloft (Sertraline)

Overview
Zoloft is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to treat major depressive disorder, obsessive compulsive disorder, panic disorder, post-traumatic stress disorder, social…

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