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Elestrin is a prescription medication approved by the U.S. Food and Drug Administration (FDA) in 1954 to treat menopause symptoms. In cases of endometriosis, Elestrin is prescribed to reduce menopause-like side effects of some hormonal medications. Elestrin is also known by its drug name, estradiol.

Elestrin should not be taken by women who are or may be pregnant. Elestrin is not appropriate for women who have a history of blood clots, stroke, heart attack, or undiagnosed vaginal bleeding. Do not take Elestrin if you have or suspect you may have breast cancer or any other estrogen-dependent cancer. Do not take Elestrin if you have a deficiency of antithrombin, protein S, or protein C. Elestrin should be used with caution in women with a history of asthma, diabetes, migraine, lupus, porphyria, and obesity, as well as those who smoke.

Elestrin is a female sex hormone. It is believed that Elestrin works in cases of endometriosis by replenishing estrogen levels decreased by other hormonal medications.

How do I take it?
If you are a woman of childbearing age, your doctor may suggest you take a pregnancy test before beginning to use Elestrin.

Elestrin gel is applied topically once a day to one arm from the shoulder to the wrist. Apply Elestrin to clean, dry skin, spreading the gel thinly. There is no need to rub the gel into your skin. Allow the gel to absorb for 10 minutes before getting dressed.

Apply Elestrin at the same time each day. Allow as much time as possible after applying Elestrin before you next bathe, swim, or sit in a sauna.

Avoid getting Elestrin into your eyes. Do not apply Elestrin to your breasts. Wash your hands thoroughly after applying Elestrin. Do not allow anyone else to apply Elestrin to your skin.

Elestrin gel is flammable. Do not smoke or stand near open flames while applying or shortly after applying Elestrin.

Elestrin may make your skin more sensitive to sunlight. Use sunscreen or wear protective clothing when you go out into the sunlight while taking Elestrin.

Store your container of Elestrin capped.

Always follow your doctor’s instructions exactly when using Elestrin.

For many years, topical estradiol (Elestrin) has been used to treat menopause symptoms such as hot flashes, vaginal dryness and discomfort, mood changes, and loss of bone density. In practice, doctors have found that prescribing low doses of topical estradiol as an “add-back” therapy can help prevent or lessen these side effects during hormonal medication for endometriosis.

Side effects
Rare but serious side effects of Elestrin can include worsening of endometriosis, endometrial cancer, breast cancer, heart attack, stroke, blood clot, and dementia.

Common side effects of Elestrin may include headache, pain or tenderness in your breasts, mood changes, weight gain, vaginal discharge or discomfort, difficulty achieving orgasm, and acne.

Call your doctor immediately if you experience bulging eyes, vision changes, sudden dizziness or confusion, trouble speaking, pain in your chest or left arm, numbness on one side of your body, yellowing of the skin or eyes, joint pain, hives, abdominal pain or tenderness, difficulty controlling your movements, or pain, warmth, or swelling in one or both legs.

Many drugs can cause allergic reactions that, in the most serious cases, can result in death. Seek immediate medical help if you experience signs of a severe allergic reaction such as difficulty breathing or swelling in the face, throat, eyes, lips, or tongue.

For more details about this treatment, visit:

Elestrin — RxList

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