Overview
Provera is a prescription drug that was approved by the Food and Drug Administration (FDA) in 1959. Provera is prescribed to prevent pregnancy and treat symptoms of endometriosis. Provera may be referred to by its drug name, medroxyprogesterone.

Provera is not appropriate for women who have a history of blood clots, stroke, heart attack, or breast cancer. Women with active liver disease or undiagnosed vaginal bleeding should not take Provera. Do not take Provera if you have shown previous hypersensitivity to medroxyprogesterone. Provera may not be appropriate for women who are pregnant or breastfeeding. Provera should be used with caution in women with a history of heart, thyroid, or kidney problems, high blood pressure, or high cholesterol.... read more


Provera is a synthetic steroid hormone, specifically a progestin. In cases of endometriosis, Provera is believed to work by changing hormone levels and controlling the growth of the uterine lining.

How do I take it?
Provera is taken as a tablet once daily.

Always follow your doctor’s instructions exactly while taking Provera.

Results
Since the 1950s, progestins such as medroxyprogesterone (Provera) have been widely prescribed to treat endometriosis. Many doctors consider progestins a safe and effective treatment for endometriosis.

Side effects
Common side effects of Provera include hot flashes, weight changes, nervousness, irritability, insomnia, leg cramps, trouble sleeping, nausea, bloating, joint or muscle pain, acne, hair growth on face, hair loss on scalp, vaginal discomfort, breast discharge, and swollen or painful breasts. Many of these side effects may fade after several weeks of taking Provera.

Some women with depression may notice that it becomes worse while taking Provera.

Notify your doctor if side effects worsen. Call your doctor if you experience vision changes, pain, swelling or warmth in one leg, bulging eyes, trouble speaking, seizures, weakness on one side, extreme fatigue, pain in your chest, jaw, or left arm, swelling in your extremities, rapid, pounding heartbeat, yellowing of the eyes or skin (jaundice), or coughing up blood while taking Provera.

Many drugs can cause allergic reactions that, in the most serious cases, can result in death. Seek immediate medical help if you experience signs of a severe allergic reaction such as difficulty breathing or swelling of the face, throat, eyes, lips, or tongue.

Provera (Medroxyprogesterone) Questions

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