Zoloft (Sertraline) for Endometriosis | MyEndometriosisTeam

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Zoloft is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to treat major depressive disorder, obsessive compulsive disorder, panic disorder, post-traumatic stress disorder, social anxiety disorder, and premenstrual dysphoric disorder. It is sometimes used off-label to treat endometriosis. Zoloft is also known by its drug name, sertraline.

Zoloft belongs to a class of drugs called antidepressants. It is known as a serotonin norepinephrine reuptake inhibitor (SNRI). Zoloft is believed to work by making serotonin and norepinephrine more available in the brain. These neurotransmitters (chemicals that send messages in the brain) are thought to relieve pain symptoms associated with endometriosis.

How do I take it?
Prescribing information states that Zoloft is taken once per day by mouth.

Zoloft comes in the form of a tablet or oral solution.

Side effects
The FDA-approved label for Zoloft lists common side effects including nausea, diarrhea or loose stool, tremor, indigestion, decreased appetite, excessive sweating, decreased sex drive, and difficulty ejaculating in men.

Rare but serious side effects listed for Zoloft include suicidal thoughts or behaviors, serotonin syndrome (a potentially life-threatening condition in which too much serotonin builds up in the body), increased risk of bleeding, seizures, glaucoma, and activation of mania.

For more details about this treatment, visit:

Zoloft — Viatris

Zoloft — RxList

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