Answer Summary

Members overwhelmingly confirmed that severe bone and muscle pain is a common side effect of Lupron injections, with many describing deep,... Read more

Members overwhelmingly confirmed that severe bone and muscle pain is a common side effect of Lupron injections, with many describing deep, achy discomfort in the hips, legs, arms, and back that can be difficult to distinguish as bone versus muscle pain. Several members shared additional side effects they experienced, including nausea, headaches, fatigue, cognitive fog (often called Lupron brain), ongoing cramping even after stopping periods, and concerns about bone density loss, with one member recommending the poster ask their doctor about norethindrone acetate to help protect against bone loss. A recurring theme was that many members either stopped Lupron early or refused to continue due to the severity and persistence of side effects, with some reporting lasting impacts years after discontinuing the medication.