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Real members of MyEndometriosisTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
November 21, 2025
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A MyEndometriosisTeam Member

Please no more Lupron. Do not trust what they tell you will help. I believe you’re going the right way with your surgical decision. Best wishes!!

January 12
A MyEndometriosisTeam Member

Its funny I went on Progesterone and started to bleed excessive than I wound normally hv on my circle. so I stopped that right away. I had embolization done but didn't change anything and made me sick for a months. Now I have taking this Lupron shot for one time so see if there will be any changes before I go in for my surgery in couple months.. I did not experience any hot flushes or sweat but I had a flu like symptoms like fever and chills then stuffed mucus. Its been few days so im waiting to see how its goes.

December 15, 2025
MyEndometriosisTeam

Has Lupron been effective for stopping excessive bleeding in endometriosis?

Lupron (leuprolide) is a GnRH agonist that works by lowering estrogen levels, which can reduce endometriosis symptoms including bleeding. It's designed to treat endometriosis pain and lesion growth rather than specifically targeting excessive Show Full Answer

Has Lupron been effective for stopping excessive bleeding in endometriosis?

Lupron (leuprolide) is a GnRH agonist that works by lowering estrogen levels, which can reduce endometriosis symptoms including bleeding. It's designed to treat endometriosis pain and lesion growth rather than specifically targeting excessive bleeding.

Some MyEndometriosisTeam members have found Lupron helpful. One member shared: "I was on Lupron for a year and it was the only thing that helped my endometriosis. There's some side effects like night sweats and hot flashes but they're manageable."

However, it's worth noting that hormonal contraceptives (birth control pills, patches, or hormonal IUDs) have been more specifically shown to reduce excessive menstrual bleeding and may be more cost-effective options to discuss with your doctor first.

One member found relief with progesterone instead: "I was bleeding 24/7 for over 1.5 years. Then I went on progesterone, and it all went away."

Since Lupron is expensive and comes with side effects like hot flashes and night sweats, it's important to discuss all your options with your gynecologist. They can help determine if Lupron is the best choice for your specific situation or if other treatments might work better for controlling your bleeding.

November 21, 2025

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